Potassium channel subfamily K member 10 (Outward rectifying potassium channel protein TREK-2) (TREK-2 K(+) channel subunit)
1_MFFLY 6_ TDFFL 11_ SLVAV 16_ PAAAP 21_ VCQPK 26_ SATNG 31_ QPPAP 36_ APTPT 41_ PRLSI 46_ SSRAT 51_ VVARM 56_ EGTSQ 61_ GGLQT 66_ VMKWK 71_ TVVAI 76_ FVVVV 81_ VYLVT 86_ GGLVF 91_ RALEQ 96_ PFESS 101_ QKNTI 106_ ALEKA 111_ EFLRD 116_ HVCVS 121_ PQELE 126_ TLIQH 131_ ALDAD 136_ NAGVS 141_ PIGNS 146_ SNNSS 151_ HWDLG 156_ SAFFF 161_ AGTVI 166_ TTIGY 171_ GNIAP 176_ STEGG 181_ KIFCI 186_ LYAIF 191_ GIPLF 196_ GFLLA 201_ GIGDQ 206_ LGTIF 211_ GKSIA 216_ RVEKV 221_ FRKKQ 226_ VSQTK 231_ IRVIS 236_ TILFI 241_ LAGCI 246_ VFVTI 251_ PAVIF 256_ KYIEG 261_ WTALE 266_ SIYFV 271_ VVTLT 276_ TVGFG 281_ DFVAG 286_ GNAGI 291_ NYREW 296_ YKPLV 301_ WFWIL 306_ VGLAY 311_ FAAVL 316_ SMIGD 321_ WLRVL 326_ SKKTK 331_ EEVGE 336_ IKAHA 341_ AEWKA 346_ NVTAE 351_ FRETR 356_ RRLSV 361_ EIHDK 366_ LQRAA 371_ TIRSM 376_ ERRRL 381_ GLDQR 386_ AHSLD 391_ MLSPE 396_ KRSVF 401_ AALDT 406_ GRFKA 411_ SSQES 416_ INNRP 421_ NNLRL 426_ KGPEQ 431_ LNKHG 436_ QGASE 441_ DNIIN 446_ KFGST 451_ SRLTK 456_ RKNKD 461_ LKKTL 466_ PEDVQ 471_ KIYKT 476_ FRNYS 481_ LDEEK 486_ KEEET 491_ EKMCN 496_ SDNSS 501_ TAMLT 506_ DCIQQ 511_ HAELE 516_ NGMIP 521_ TDTKD 526_ REPEN 531_NSLLE
1: K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Converts to voltage-independent 'leak' conductance mode upon stimulation by various stimuli including mechanical membrane stretch, acidic pH, heat and lipids (PubMed:10880510, PubMed:25766236, PubMed:26919430, PubMed:38605031). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:30573346). In trigeminal ganglia sensory neurons, the heterodimer of KCNK10/TREK-2 and KCNK18/TRESK inhibits neuronal firing and neurogenic inflammation by stabilizing the resting membrane potential at K(+) equilibrium potential as well as by regulating the threshold of action potentials and the spike frequency (By similarity). Permeable to other monovalent ions such as Rb(+) and Cs(+) (PubMed:26919430)