Sestrin-3 (EC 1.11.1.-)
1_MNRGG 6_ GSPSA 11_ AANYL 16_ LCTNC 21_ RKVLR 26_ KDKRI 31_ RVSQP 36_ LTRGP 41_ SAFIP 46_ EKEVV 51_ QANTV 56_ DERTN 61_ FLVEE 66_ YSTSG 71_ RLDNI 76_ TQVMS 81_ LHTQY 86_ LESFL 91_ RSQFY 96_ MLRMD 101_ GPLPL 106_ PYRHY 111_ IAIMA 116_ AARHQ 121_ CSYLI 126_ NMHVD 131_ EFLKT 136_ GGIAE 141_ WLNGL 146_ EYVPQ 151_ RLKNL 156_ NEINK 161_ LLAHR 166_ PWLIT 171_ KEHIQ 176_ KLVKT 181_ GENNW 186_ SLPEL 191_ VHAVV 196_ LLAHY 201_ HALAS 206_ FVFGS 211_ GINPE 216_ RDPEI 221_ SNGFR 226_ LISVN 231_ NFCVC 236_ DLAND 241_ NNIEN 246_ ASLSG 251_ SNFGI 256_ VDSLS 261_ ELEAL 266_ MERMK 271_ RLQEE 276_ REDEE 281_ ASQEE 286_ MSTRF 291_ EKEKK 296_ ESLFV 301_ VSGDT 306_ FHSFP 311_ HSDFE 316_ DDMII 321_ TSDVS 326_ RYIED 331_ PGFGY 336_ EDFAR 341_ RGEEH 346_ LPTFR 351_ AQDYT 356_ WENHG 361_ FSLVN 366_ RLYSD 371_ IGHLL 376_ DEKFR 381_ MVYNL 386_ TYNTM 391_ ATHED 396_ VDTTM 401_ LRRAL 406_ FNYVH 411_ CMFGI 416_ RYDDY 421_ DYGEV 426_ NQLLE 431_ RSLKV 436_ YIKTV 441_ TCYPE 446_ RTTKR 451_ MYDSY 456_ WRQFK 461_ HSEKV 466_ HVNLL 471_ LMEAR 476_ MQAEL 481_ LYALR 486_AITRH
1: May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway (PubMed:25263562). May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity). This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity)