Forkhead box protein L2
1_MMASY 6_ PEPED 11_ AAGAL 16_ LAPET 21_ GRTVK 26_ EPEGP 31_ PPSPG 36_ KGGGG 41_ GGGTA 46_ PEKPD 51_ PAQKP 56_ PYSYV 61_ ALIAM 66_ AIRES 71_ AEKRL 76_ TLSGI 81_ YQYII 86_ AKFPF 91_ YEKNK 96_ KGWQN 101_ SIRHN 106_ LSLNE 111_ CFIKV 116_ PREGG 121_ GERKG 126_ NYWTL 131_ DPACE 136_ DMFEK 141_ GNYRR 146_ RRRMK 151_ RPFRP 156_ PPAHF 161_ QPGKG 166_ LFGAG 171_ GAAGG 176_ CGVAG 181_ AGADG 186_ YGYLA 191_ PPKYL 196_ QSGFL 201_ NNSWP 206_ LPQPP 211_ SPMPY 216_ ASCQM 221_ AAAAA 226_ AAAAA 231_ AAAAG 236_ PGSPG 241_ AAAVV 246_ KGLAG 251_ PAASY 256_ GPYTR 261_ VQSMA 266_ LPPGV 271_ VNSYN 276_ GLGGP 281_ PAAPP 286_ PPPHP 291_ HPHPH 296_ AHHLH 301_ AAAAP 306_ PPAPP 311_ HHGAA 316_ APPPG 321_ QLSPA 326_ SPATA 331_ APPAP 336_ APTSA 341_ PGLQF 346_ ACARQ 351_ PELAM 356_ MHCSY 361_ WDHDS 366_ KTGAL 371_HSRLD
1: Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2