Inhibin beta E chain (Activin beta-E chain)
1_MRLPD 6_ VQLWL 11_ VLLWA 16_ LVRAQ 21_ GTGSV 26_ CPSCG 31_ GSKLA 36_ PQAER 41_ ALVLE 46_ LAKQQ 51_ ILDGL 56_ HLTSR 61_ PRITH 66_ PPPQA 71_ ALTRA 76_ LRRLQ 81_ PGSVA 86_ PGNGE 91_ EVISF 96_ ATVTD 101_ STSAY 106_ SSLLT 111_ FHLST 116_ PRSHH 121_ LYHAR 126_ LWLHV 131_ LPTLP 136_ GTLCL 141_ RIFRW 146_ GPRRR 151_ RQGSR 156_ TLLAE 161_ HHITN 166_ LGWHT 171_ LTLPS 176_ SGLRG 181_ EKSGV 186_ LKLQL 191_ DCRPL 196_ EGNST 201_ VTGQP 206_ RRLLD 211_ TAGHQ 216_ QPFLE 221_ LKIRA 226_ NEPGA 231_ GRARR 236_ RTPTC 241_ EPATP 246_ LCCRR 251_ DHYVD 256_ FQELG 261_ WRDWI 266_ LQPEG 271_ YQLNY 276_ CSGQC 281_ PPHLA 286_ GSPGI 291_ AASFH 296_ SAVFS 301_ LLKAN 306_ NPWPA 311_ STSCC 316_ VPTAR 321_ RPLSL 326_ LYLDH 331_ NGNVV 336_ KTDVP 341_DMVVE
1: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins
2: Activin E is a homodimer of INHBE secreted by the liver that plays a crucial role in regulating metabolic homeostasis particularly in lipid metabolism and energy homeostasis. Plays a central role in the regulation of adipose tissue lipolysis by preventing the influx of fatty acids from adipose tissue into the liver. Mechanistically, signals via ACVR1C to activate SMAD2/3 signaling, suppressing PPARG target genes in adipose tissue, thereby reducing liver lipid content and improving glycemic control (PubMed:38533769). Induces beige adipocyte formation and thermogenesis in response to cold exposure (By similarity)