Prokineticin-1 (Endocrine-gland-derived vascular endothelial growth factor) (EG-VEGF) (Mambakine)
1_MRGAT 6_ RVSIM 11_ LLLVT 16_ VSDCA 21_ VITGA 26_ CERDV 31_ QCGAG 36_ TCCAI 41_ SLWLR 46_ GLRMC 51_ TPLGR 56_ EGEEC 61_ HPGSH 66_ KVPFF 71_ RKRKH 76_ HTCPC 81_ LPNLL 86_ CSRFP 91_ DGRYR 96_CSMDL
1: Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis