Visual system homeobox 2 (Ceh-10 homeodomain-containing homolog) (Homeobox protein CHX10)
1_MTGKA 6_ GEALS 11_ KPKSE 16_ TVAKS 21_ TSGGA 26_ PARCT 31_ GFGIQ 36_ EILGL 41_ NKEPP 46_ SSHPR 51_ AALDG 56_ LAPGH 61_ LLAAR 66_ SVLSP 71_ AGVGG 76_ MGLLG 81_ PGGLP 86_ GFYTQ 91_ PTFLE 96_ VLSDP 101_ QSVHL 106_ QPLGR 111_ ASGPL 116_ DTSQT 121_ ASSDS 126_ EDVSS 131_ SDRKM 136_ SKSAL 141_ NQTKK 146_ RKKRR 151_ HRTIF 156_ TSYQL 161_ EELEK 166_ AFNEA 171_ HYPDV 176_ YAREM 181_ LAMKT 186_ ELPED 191_ RIQVW 196_ FQNRR 201_ AKWRK 206_ REKCW 211_ GRSSV 216_ MAEYG 221_ LYGAM 226_ VRHSI 231_ PLPES 236_ ILKSA 241_ KDGIM 246_ DSCAP 251_ WLLGM 256_ HKKSL 261_ EAAAE 266_ SGRKP 271_ EGERQ 276_ ALPKL 281_ DKMEQ 286_ DERGP 291_ DAQAA 296_ ISQEE 301_ LRENS 306_ IAVLR 311_ AKAQE 316_ HSTKV 321_ LGTVS 326_ GPDSL 331_ ARSTE 336_ KPEEE 341_ EAMDE 346_ DRPAE 351_ RLSPP 356_QLEDM
1: Acts as a transcriptional regulator through binding to DNA at the consensus sequence 5'-[TC]TAATT[AG][AG]-3' upstream of gene promoters (PubMed:27301076). Plays a significant role in the specification and morphogenesis of the sensory retina (By similarity). May play a role in specification of V2a interneurons during spinal cord development (By similarity). Mediates differentiation of V2a interneurons by repression of motor neuron gene transcription, via competitively binding to response elements that are activated by the ISL1-LHX3 complex, such as VSX1 (PubMed:17919464, PubMed:27477290). Acts as a positive transcriptional regulator of NXNL1; regulation is significantly increased in synergy with VSX1 (By similarity). Acts as a negative transcriptional regulator of MITF (By similarity). Represses SAG transcription by competitive inhibition of ISL1-LHX3 response elements (PubMed:16236706, PubMed:27477290). Binds to the photoreceptor conserved element-1 (PCE-1) in the promoter of rod photoreceptor arrestin SAG and acts as a transcriptional repressor (By similarity). Involved in the development of retinal ganglion cells (RGCs) which leads to release of SHH by RGCs, promoting Hedgehog signaling and subsequent proliferation of retinal progenitor cells (By similarity). Participates in the development of the cells of the inner nuclear layer, by promoting postnatal differentiation of bipolar cells with a comparable inhibition of rod cell differentiation (By similarity). May play a role in the maintenance of neural retina identity during development by regulation of canonical Wnt genes and CTNNB1 localization, suggesting a role in the regulation of canonical Wnt signaling (PubMed:27301076)