Anthrax toxin receptor 2 (Capillary morphogenesis gene 2 protein) (CMG-2)
1_MVAER 6_ SPARS 11_ PGSWL 16_ FPGLW 21_ LLVLS 26_ GPGGL 31_ LRAQE 36_ QPSCR 41_ RAFDL 46_ YFVLD 51_ KSGSV 56_ ANNWI 61_ EIYNF 66_ VQQLA 71_ ERFVS 76_ PEMRL 81_ SFIVF 86_ SSQAT 91_ IILPL 96_ TGDRG 101_ KISKG 106_ LEDLK 111_ RVSPV 116_ GETYI 121_ HEGLK 126_ LANEQ 131_ IQKAG 136_ GLKTS 141_ SIIIA 146_ LTDGK 151_ LDGLV 156_ PSYAE 161_ KEAKI 166_ SRSLG 171_ ASVYC 176_ VGVLD 181_ FEQAQ 186_ LERIA 191_ DSKEQ 196_ VFPVK 201_ GGFQA 206_ LKGII 211_ NSILA 216_ QSCTE 221_ ILELQ 226_ PSSVC 231_ VGEEF 236_ QIVLS 241_ GRGFM 246_ LGSRN 251_ GSVLC 256_ TYTVN 261_ ETYTT 266_ SVKPV 271_ SVQLN 276_ SMLCP 281_ APILN 286_ KAGET 291_ LDVSV 296_ SFNGG 301_ KSVIS 306_ GSLIV 311_ TATEC 316_ SNGIA 321_ AIIVI 326_ LVLLL 331_ LLGIG 336_ LMWWF 341_ WPLCC 346_ KVVIK 351_ DPPPP 356_ PAPAP 361_ KEEEE 366_ EPLPT 371_ KKWPT 376_ VDASY 381_ YGGRG 386_ VGGIK 391_ RMEVR 396_ WGDKG 401_ STEEG 406_ ARLEK 411_ AKNAV 416_ VKIPE 421_ ETEEP 426_ IRPRP 431_ PRPKP 436_ THQPP 441_ QTKWY 446_ TPIKG 451_ RLDAL 456_ WALLR 461_ RQYDR 466_ VSLMR 471_ PQEGD 476_ EVCIW 481_ECIEK
1: Necessary for cellular interactions with laminin and the extracellular matrix
2: (Microbial infection) Receptor for the protective antigen (PA) of B.anthracis (PubMed:12700348, PubMed:15243628, PubMed:15326297). Binding of PA leads to heptamerization of the receptor-PA complex (PubMed:12700348, PubMed:15243628, PubMed:15326297). Upon binding of the PA of B.anthracis, the complex moves to glycosphingolipid-rich lipid rafts, where it is internalized via a clathrin-dependent pathway (PubMed:12551953, PubMed:15337774). In the endosomal membrane, at pH under 7, the complex then rearranges and forms a pore allowing the other components of anthrax toxin to escape to the cytoplasm (PubMed:12551953, PubMed:15337774)