Myeloid leukemia factor 1 (Myelodysplasia-myeloid leukemia factor 1)
1_MFRML 6_ NSSFE 11_ DDPFF 16_ SESIL 21_ AHREN 26_ MRQMI 31_ RSFSE 36_ PFGRD 41_ LLSIS 46_ DGRGR 51_ AHNRR 56_ GHNDG 61_ EDSLT 66_ HTDVS 71_ SFQTM 76_ DQMVS 81_ NMRNY 86_ MQKLE 91_ RNFGQ 96_ LSVDP 101_ NGHSF 106_ CSSSV 111_ MTYSK 116_ IGDEP 121_ PKVFQ 126_ ASTQT 131_ RRAPG 136_ GIKET 141_ RKAMR 146_ DSDSG 151_ LEKMA 156_ IGHHI 161_ HDRAH 166_ VIKKS 171_ KNKKT 176_ GDEEV 181_ NQEFI 186_ NMNES 191_ DAHAF 196_ DEEWQ 201_ SEVLK 206_ YKPGR 211_ HNLGN 216_ TRMRS 221_ VGHEN 226_ PGSRE 231_ LKRRE 236_ KPQQS 241_ PAIEH 246_ GRRSN 251_ VLGDK 256_ LHIKG 261_SSVKS
1: Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus