Toll/interleukin-1 receptor domain-containing adapter protein (TIR domain-containing adapter protein) (Adaptor protein Wyatt) (MyD88 adapter-like protein) (MyD88-2)
1_MASST 6_ SLPAP 11_ GSRPK 16_ KPLGK 21_ MADWF 26_ RQTLL 31_ KKPKK 36_ RPNSP 41_ ESTSS 46_ DASQP 51_ TSQDS 56_ PLPPS 61_ LSSVT 66_ SPSLP 71_ PTHAS 76_ DSGSS 81_ RWSKD 86_ YDVCV 91_ CHSEE 96_ DLVAA 101_ QDLVS 106_ YLEGS 111_ TASLR 116_ CFLQL 121_ RDATP 126_ GGAIV 131_ SELCQ 136_ ALSSS 141_ HCRVL 146_ LITPG 151_ FLQDP 156_ WCKYQ 161_ MLQAL 166_ TEAPG 171_ AEGCT 176_ IPLLS 181_ GLSRA 186_ AYPPE 191_ LRFMY 196_ YVDGR 201_ GPDGG 206_ FRQVK 211_ EAVMR 216_YLQTL
1: Adapter involved in TLR2, TLR4 and RAGE signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha (TNF) and interleukin-6 (IL6)