NACHT, LRR and PYD domains-containing protein 6 (Angiotensin II/vasopressin receptor) (PYRIN-containing APAF1-like protein 5)
1_MDQPE 6_ APCSS 11_ TGPRL 16_ AVARE 21_ LLLAA 26_ LEELS 31_ QEQLK 36_ RFRHK 41_ LRDVG 46_ PDGRS 51_ IPWGR 56_ LERAD 61_ AVDLA 66_ EQLAQ 71_ FYGPE 76_ PALEV 81_ ARKTL 86_ KRADA 91_ RDVAA 96_ QLQER 101_ RLQRL 106_ GLGSG 111_ TLLSV 116_ SEYKK 121_ KYREH 126_ VLQLH 131_ ARVKE 136_ RNARS 141_ VKITK 146_ RFTKL 151_ LIAPE 156_ SAAPE 161_ EAMGP 166_ AEEPE 171_ PGRAR 176_ RSDTH 181_ TFNRL 186_ FRRDE 191_ EGRRP 196_ LTVVL 201_ QGPAG 206_ IGKTM 211_ AAKKI 216_ LYDWA 221_ AGKLY 226_ QGQVD 231_ FAFFM 236_ PCGEL 241_ LERPG 246_ TRSLA 251_ DLILD 256_ QCPDR 261_ GAPVP 266_ QMLAQ 271_ PQRLL 276_ FILDG 281_ ADELP 286_ ALGGP 291_ EAAPC 296_ TDPFE 301_ AASGA 306_ RVLGG 311_ LLSKA 316_ LLPTA 321_ LLLVT 326_ TRAAA 331_ PGRLQ 336_ GRLCS 341_ PQCAE 346_ VRGFS 351_ DKDKK 356_ KYFYK 361_ YFRDE 366_ RRAER 371_ AYRFV 376_ KENET 381_ LFALC 386_ FVPFV 391_ CWIVC 396_ TVLRQ 401_ QLELG 406_ RDLSR 411_ TSKTT 416_ TSVYL 421_ LFITS 426_ VLSSA 431_ PVADG 436_ PRLQG 441_ DLRNL 446_ CRLAR 451_ EGVLG 456_ RRAQF 461_ AEKEL 466_ EQLEL 471_ RGSKV 476_ QTLFL 481_ SKKEL 486_ PGVLE 491_ TEVTY 496_ QFIDQ 501_ SFQEF 506_ LAALS 511_ YLLED 516_ GGVPR 521_ TAAGG 526_ VGTLL 531_ RGDAQ 536_ PHSHL 541_ VLTTR 546_ FLFGL 551_ LSAER 556_ MRDIE 561_ RHFGC 566_ MVSER 571_ VKQEA 576_ LRWVQ 581_ GQGQG 586_ CPGVA 591_ PEVTE 596_ GAKGL 601_ EDTEE 606_ PEEEE 611_ EGEEP 616_ NYPLE 621_ LLYCL 626_ YETQE 631_ DAFVR 636_ QALCR 641_ FPELA 646_ LQRVR 651_ FCRMD 656_ VAVLS 661_ YCVRC 666_ CPAGQ 671_ ALRLI 676_ SCRLV 681_ AAQEK 686_ KKKSL 691_ GKRLQ 696_ ASLGG 701_ GSSSQ 706_ GTTKQ 711_ LPASL 716_ LHPLF 721_ QAMTD 726_ PLCHL 731_ SSLTL 736_ SHCKL 741_ PDAVC 746_ RDLSE 751_ ALRAA 756_ PALTE 761_ LGLLH 766_ NRLSE 771_ AGLRM 776_ LSEGL 781_ AWPQC 786_ RVQTV 791_ RVQLP 796_ DPQRG 801_ LQYLV 806_ GMLRQ 811_ SPALT 816_ TLDLS 821_ GCQLP 826_ APMVT 831_ YLCAV 836_ LQHQG 841_ CGLQT 846_ LSLAS 851_ VELSE 856_ QSLQE 861_ LQAVK 866_ RAKPD 871_ LVITH 876_ PALDG 881_ HPQPP 886_KELIS
1: Acts as the sensor component of the NLRP6 inflammasome, which mediates inflammasome activation in response to various pathogen-associated signals, leading to maturation and secretion of IL1B and IL18 (PubMed:30392956, PubMed:34678144). Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation (PubMed:30674671). Acts as a recognition receptor (PRR): recognizes and binds specific pathogens and other damage-associated signals, such as lipoteichoic acid (LTA), a cell-wall component of Gram-positive bacteria, or double stranded RNA (dsRNA) (PubMed:30392956, PubMed:33377178, PubMed:34678144). May also recognize and bind lipopolysaccharide (LPS), a major component of the outer membrane of Gram-negative bacteria; however, LPS is probably not a major activator of the NLRP6 inflammasome (PubMed:31932628, PubMed:34678144). Following LTA- or dsRNA-binding, NLRP6 undergoes liquid-liquid phase separation (LLPS), enhancing multivalent interactions, an essential step for the formation of the NLRP6 inflammasome polymeric complex (PubMed:34678144). The NLRP6 inflammasome acts by promoting recruitment of effector pro-inflammatory caspases (CASP1 and/or CASP4) that catalyze maturation and secretion of IL1B and IL18 in the extracellular milieu (PubMed:12387869, PubMed:30392956, PubMed:30674671, PubMed:34678144). The NLRP6 inflammasome plays a central role in the maintenance of epithelial integrity and host defense against microbial infections in the intestine (PubMed:30392956). Required to restrict infection against Gram-positive bacteria by recognizing lipoteichoic acid (LTA), leading to recruitment of CASP4 and CASP1, and subsequent maturation and secretion of IL1B and IL18 (PubMed:30392956, PubMed:33377178). Involved in intestinal antiviral innate immunity together with DHX15: recognizes and binds viral dsRNA to restrict infection by enteric viruses through the interferon pathway and GSDMD-dependent release of IL18 (PubMed:34161762, PubMed:34678144). Required to prevent infection by the apicomplexan parasite Cryptosporidium in enterocytes by promoting GSDMD-dependent release of IL18 (By similarity). The NLRP6 inflammasome may also regulate the gut microbiota composition by acting as a sensor of microbiota-associated metabolites to form a PYCARD/ASC-dependent inflammasome for downstream IL18 release and secretion of antimicrobial peptides (By similarity). Essential for gut mucosal self-renewal and proliferation (By similarity). Regulate mucus secretion in an inflammasome- and autophagy-dependent manner to prevent invasion by enteric bacteria, (By similarity). During systemic bacterial infections, the NLRP6 inflammasome negatively regulates neutrophil recruitment and neutrophil extracellular traps (NETs) formation (By similarity). May promote peripheral nerve recovery following injury via an inflammasome-independent mechanism (By similarity)