NACHT, LRR and PYD domains-containing protein 12 (Monarch-1) (PYRIN-containing APAF1-like protein 7) (Regulated by nitric oxide)
1_MLRTA 6_ GRDGL 11_ CRLST 16_ YLEEL 21_ EAVEL 26_ KKFKL 31_ YLGTA 36_ TELGE 41_ GKIPW 46_ GSMEK 51_ AGPLE 56_ MAQLL 61_ ITHFG 66_ PEEAW 71_ RLALS 76_ TFERI 81_ NRKDL 86_ WERGQ 91_ REDLV 96_ RDTPP 101_ GGPSS 106_ LGNQS 111_ TCLLE 116_ VSLVT 121_ PRKDP 126_ QETYR 131_ DYVRR 136_ KFRLM 141_ EDRNA 146_ RLGEC 151_ VNLSH 156_ RYTRL 161_ LLVKE 166_ HSNPM 171_ QVQQQ 176_ LLDTG 181_ RGHAR 186_ TVGHQ 191_ ASPIK 196_ IETLF 201_ EPDEE 206_ RPEPP 211_ RTVVM 216_ QGAAG 221_ IGKSM 226_ LAHKV 231_ MLDWA 236_ DGKLF 241_ QGRFD 246_ YLFYI 251_ NCREM 256_ NQSAT 261_ ECSMQ 266_ DLIFS 271_ CWPEP 276_ SAPLQ 281_ ELIRV 286_ PERLL 291_ FIIDG 296_ FDELK 301_ PSFHD 306_ PQGPW 311_ CLCWE 316_ EKRPT 321_ ELLLN 326_ SLIRK 331_ KLLPE 336_ LSLLI 341_ TTRPT 346_ ALEKL 351_ HRLLE 356_ HPRHV 361_ EILGF 366_ SEAER 371_ KEYFY 376_ KYFHN 381_ AEQAG 386_ QVFNY 391_ VRDNE 396_ PLFTM 401_ CFVPL 406_ VCWVV 411_ CTCLQ 416_ QQLEG 421_ GGLLR 426_ QTSRT 431_ TTAVY 436_ MLYLL 441_ SLMQP 446_ KPGAP 451_ RLQPP 456_ PNQRG 461_ LCSLA 466_ ADGLW 471_ NQKIL 476_ FEEQD 481_ LRKHG 486_ LDGED 491_ VSAFL 496_ NMNIF 501_ QKDIN 506_ CERYY 511_ SFIHL 516_ SFQEF 521_ FAAMY 526_ YILDE 531_ GEGGA 536_ GPDQD 541_ VTRLL 546_ TEYAF 551_ SERSF 556_ LALTS 561_ RFLFG 566_ LLNEE 571_ TRSHL 576_ EKSLC 581_ WKVSP 586_ HIKMD 591_ LLQWI 596_ QSKAQ 601_ SDGST 606_ LQQGS 611_ LEFFS 616_ CLYEI 621_ QEEEF 626_ IQQAL 631_ SHFQV 636_ IVVSN 641_ IASKM 646_ EHMVS 651_ SFCLK 656_ RCRSA 661_ QVLHL 666_ YGATY 671_ SADGE 676_ DRARC 681_ SAGAH 686_ TLLVQ 691_ LPERT 696_ VLLDA 701_ YSEHL 706_ AAALC 711_ TNPNL 716_ IELSL 721_ YRNAL 726_ GSRGV 731_ KLLCQ 736_ GLRHP 741_ NCKLQ 746_ NLRLK 751_ RCRIS 756_ SSACE 761_ DLSAA 766_ LIANK 771_ NLTRM 776_ DLSGN 781_ GVGFP 786_ GMMLL 791_ CEGLR 796_ HPQCR 801_ LQMIQ 806_ LRKCQ 811_ LESGA 816_ CQEMA 821_ SVLGT 826_ NPHLV 831_ ELDLT 836_ GNALE 841_ DLGLR 846_ LLCQG 851_ LRHPV 856_ CRLRT 861_ LWLKI 866_ CRLTA 871_ AACDE 876_ LASTL 881_ SVNQS 886_ LRELD 891_ LSLNE 896_ LGDLG 901_ VLLLC 906_ EGLRH 911_ PTCKL 916_ QTLRL 921_ GICRL 926_ GSAAC 931_ EGLSV 936_ VLQAN 941_ HNLRE 946_ LDLSF 951_ NDLGD 956_ WGLWL 961_ LAEGL 966_ QHPAC 971_ RLQKL 976_ WLDSC 981_ GLTAK 986_ ACENL 991_ YFTLG 996_ INQTL 1001_ TDLYL 1006_ TNNAL 1011_ GDTGV 1016_ RLLCK 1021_ RLSHP 1026_ GCKLR 1031_ VLWLF 1036_ GMDLN 1041_ KMTHS 1046_ RLAAL 1051_ RVTKP 1056_YLDIG
1: Plays an essential role as an potent mitigator of inflammation (PubMed:30559449). Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways (PubMed:15489334, PubMed:17947705). Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway (PubMed:30559449). In turn, promotes bacterial tolerance (PubMed:30559449). Also inhibits the RIGI-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked RIGI activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked RIGI degradation (PubMed:30902577). Also acts as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue (By similarity)