Neutrophil defensin 3 (Defensin, alpha 3) (HNP-3) (HP-3) (HP3) [Cleaved into: HP 3-56; Neutrophil defensin 2 (HNP-2) (HP-2) (HP2)]
1_MRTLA 6_ ILAAI 11_ LLVAL 16_ QAQAE 21_ PLQAR 26_ ADEVA 31_ AAPEQ 36_ IAADI 41_ PEVVV 46_ SLAWD 51_ ESLAP 56_ KHPGS 61_ RKNMD 66_ CYCRI 71_ PACIA 76_ GERRY 81_ GTCIY 86_QGRLW
1: Effector molecule of the innate immune system that acts via antibiotic-like properties against a broad array of infectious agents including bacteria, fungi, and viruses (PubMed:15616305, PubMed:15772169, PubMed:17142766). Possesses the ability to neutralize bacterial toxins such as B.anthracis lethal factor, Clostridium difficile cytotoxin B as well as leukocidin produced by Staphylococcus aureus (PubMed:15772169, PubMed:18435932, PubMed:25963798). Also blocks herpes simplex virus infection by interacting with envelope glycoprotein B and thus preventing its binding to heparan sulfate, the receptor for attachment (PubMed:17142766)