Leukocyte immunoglobulin-like receptor subfamily A member 4 (CD85 antigen-like family member G) (Immunoglobulin-like transcript 7) (ILT-7) (CD antigen CD85g)
1_MTLIL 6_ TSLLF 11_ FGLSL 16_ GPRTR 21_ VQAEN 26_ LLKPI 31_ LWAEP 36_ GPVIT 41_ WHNPV 46_ TIWCQ 51_ GTLEA 56_ QGYRL 61_ DKEGN 66_ SMSRH 71_ ILKTL 76_ ESENK 81_ VKLSI 86_ PSMMW 91_ EHAGR 96_ YHCYY 101_ QSPAG 106_ WSEPS 111_ DPLEL 116_ VVTAY 121_ SRPTL 126_ SALPS 131_ PVVTS 136_ GVNVT 141_ LRCAS 146_ RLGLG 151_ RFTLI 156_ EEGDH 161_ RLSWT 166_ LNSHQ 171_ HNHGK 176_ FQALF 181_ PMGPL 186_ TFSNR 191_ GTFRC 196_ YGYEN 201_ NTPYV 206_ WSEPS 211_ DPLQL 216_ LVSGV 221_ SRKPS 226_ LLTLQ 231_ GPVVT 236_ PGENL 241_ TLQCG 246_ SDVGY 251_ IRYTL 256_ YKEGA 261_ DGLPQ 266_ RPGRQ 271_ PQAGL 276_ SQANF 281_ TLSPV 286_ SRSYG 291_ GQYRC 296_ YGAHN 301_ VSSEW 306_ SAPSD 311_ PLDIL 316_ IAGQI 321_ SDRPS 326_ LSVQP 331_ GPTVT 336_ SGEKV 341_ TLLCQ 346_ SWDPM 351_ FTFLL 356_ TKEGA 361_ AHPPL 366_ RLRSM 371_ YGAHK 376_ YQAEF 381_ PMSPV 386_ TSAHA 391_ GTYRC 396_ YGSRS 401_ SNPYL 406_ LSHPS 411_ EPLEL 416_ VVSGA 421_ TETLN 426_ PAQKK 431_ SDSKT 436_ APHLQ 441_ DYTVE 446_ NLIRM 451_ GVAGL 456_ VLLFL 461_ GILLF 466_ EAQHS 471_ QRSPP 476_ RCSQE 481_ ANSRK 486_ DNAPF 491_RVVEP
1: Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as a negative regulator of TLR7 and TLR9 signaling cascades (PubMed:16735691, PubMed:19564354, PubMed:24586760). Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells (PubMed:26172439). Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) (PubMed:16735691, PubMed:19564354). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells (PubMed:24586760)