Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC)
1_MTATL 6_ RPYLS 11_ AVRAT 16_ LQAAL 21_ CLENF 26_ SSQVV 31_ ERHNK 36_ PEVEV 41_ RSSKE 46_ LLLQP 51_ VTISR 56_ NEKEK 61_ VLIEG 66_ SINSV 71_ RVSIA 76_ VKQAD 81_ EIEKI 86_ LCHKF 91_ MRFMM 96_ MRAEN 101_ FFILR 106_ RKPVE 111_ GYDIS 116_ FLITN 121_ FHTEQ 126_ MYKHK 131_ LVDFV 136_ IHFME 141_ EIDKE 146_ ISEMK 151_ LSVNA 156_ RARIV 161_AEEFL
1: Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947)