Transcription elongation factor 1 homolog
1_MGRRK 6_ SKRKP 11_ PPKKK 16_ MTGTL 21_ ETQFT 26_ CPFCN 31_ HEKSC 36_ DVKMD 41_ RARNT 46_ GVISC 51_ TVCLE 56_ EFQTP 61_ ITYLS 66_ EPVDV 71_ YSDWI 76_DACEA
1: Factor involved in transcription-coupled nucleotide excision repair (TC-NER), a mechanism that rapidly removes RNA polymerase II-blocking lesions from the transcribed strand of active genes (PubMed:34108662, PubMed:34108663, PubMed:38316879). Acts as a key adapter required to anchor TC-NER factors to RNA polymerase II: stably positions UVSSA and the DCX(ERCC8) complex (also named CSA complex) on arrested RNA polymerase II, leading to neddylation and activation of the DCX(ERCC8) complex and ubiquitination of RNA polymerase II (PubMed:38316879)