Anaphase-promoting complex subunit 15 (APC15)
1_MSTLF 6_ PSLFP 11_ RVTET 16_ LWFNL 21_ DRPCV 26_ EETEL 31_ QQQEQ 36_ QHQAW 41_ LQSIA 46_ EKDNN 51_ LVPIG 56_ KPASE 61_ HYDDE 66_ EEEDD 71_ EDDED 76_ SEEDS 81_ EDDED 86_ MQDMD 91_ EMNDY 96_ NESPD 101_ DGEVN 106_ EVDME 111_ GNEQD 116_QDQWM
1: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:21926987). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the spindle assembly checkpoint (PubMed:21926987). Also required for degradation of CDC20 (PubMed:21926987)