Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase)
1_MAPSR 6_ KFFVG 11_ GNWKM 16_ NGRKQ 21_ SLGEL 26_ IGTLN 31_ AAKVP 36_ ADTEV 41_ VCAPP 46_ TAYID 51_ FARQK 56_ LDPKI 61_ AVAAQ 66_ NCYKV 71_ TNGAF 76_ TGEIS 81_ PGMIK 86_ DCGAT 91_ WVVLG 96_ HSERR 101_ HVFGE 106_ SDELI 111_ GQKVA 116_ HALAE 121_ GLGVI 126_ ACIGE 131_ KLDER 136_ EAGIT 141_ EKVVF 146_ EQTKV 151_ IADNV 156_ KDWSK 161_ VVLAY 166_ EPVWA 171_ IGTGK 176_ TATPQ 181_ QAQEV 186_ HEKLR 191_ GWLKS 196_ NVSDA 201_ VAQST 206_ RIIYG 211_ GSVTG 216_ ATCKE 221_ LASQP 226_ DVDGF 231_ LVGGA 236_ SLKPE 241_FVDII
1: Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis
2: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids