Eukaryotic translation initiation factor 3 subunit E (eIF3e) (Eukaryotic translation initiation factor 3 subunit 6) (Viral integration site protein INT-6 homolog) (eIF-3 p48)
1_MAEYD 6_ LTTRI 11_ AHFLD 16_ RHLVF 21_ PLLEF 26_ LSVKE 31_ IYNEK 36_ ELLQG 41_ KLDLL 46_ SDTNM 51_ VDFAM 56_ DVYKN 61_ LYSDD 66_ IPHAL 71_ REKRT 76_ TVVAQ 81_ LKQLQ 86_ AETEP 91_ IVKMF 96_ EDPET 101_ TRQMQ 106_ STRDG 111_ RMLFD 116_ YLADK 121_ HGFRQ 126_ EYLDT 131_ LYRYA 136_ KFQYE 141_ CGNYS 146_ GAAEY 151_ LYFFR 156_ VLVPA 161_ TDRNA 166_ LSSLW 171_ GKLAS 176_ EILMQ 181_ NWDAA 186_ MEDLT 191_ RLKET 196_ IDNNS 201_ VSSPL 206_ QSLQQ 211_ RTWLI 216_ HWSLF 221_ VFFNH 226_ PKGRD 231_ NIIDL 236_ FLYQP 241_ QYLNA 246_ IQTMC 251_ PHILR 256_ YLTTA 261_ VITNK 266_ DVRKR 271_ RQVLK 276_ DLVKV 281_ IQQES 286_ YTYKD 291_ PITEF 296_ VECLY 301_ VNFDF 306_ DGAQK 311_ KLREC 316_ ESVLV 321_ NDFFL 326_ VACLE 331_ DFIEN 336_ ARLFI 341_ FETFC 346_ RIHQC 351_ ISINM 356_ LADKL 361_ NMTPE 366_ EAERW 371_ IVNLI 376_ RNARL 381_ DAKID 386_ SKLGH 391_ VVMGN 396_ NAVSP 401_ YQQVI 406_ EKTKS 411_ LSFRS 416_ QMLAM 421_ NIEKK 426_ LNQNS 431_ RSEAP 436_NWATQ
1: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway (PubMed:17468741). May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins (PubMed:17310990, PubMed:17324924)