Nanos homolog 2 (NOS-2)
1_MQLPP 6_ FDMWK 11_ DYFNL 16_ SQVVW 21_ ALIAS 26_ RGQRL 31_ ETQEI 36_ EEPSP 41_ GPPLG 46_ QDQGL 51_ GAPGA 56_ NGGLG 61_ TLCNF 66_ CKHNG 71_ ESRHV 76_ YSSHQ 81_ LKTPD 86_ GVVVC 91_ PILRH 96_ YVCPV 101_ CGATG 106_ DQAHT 111_ LKYCP 116_ LNGGQ 121_ QSLYR 126_ RSGRN 131_SAGRR
1: Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity)