Serine/threonine-protein phosphatase 4 catalytic subunit (PP4C) (Pp4) (EC 3.1.3.16) (Protein phosphatase X) (PP-X)
1_MAEIS 6_ DLDRQ 11_ IEQLR 16_ RCELI 21_ KESEV 26_ KALCA 31_ KAREI 36_ LVEES 41_ NVQRV 46_ DSPVT 51_ VCGDI 56_ HGQFY 61_ DLKEL 66_ FRVGG 71_ DVPET 76_ NYLFM 81_ GDFVD 86_ RGFYS 91_ VETFL 96_ LLLAL 101_ KVRYP 106_ DRITL 111_ IRGNH 116_ ESRQI 121_ TQVYG 126_ FYDEC 131_ LRKYG 136_ SVTVW 141_ RYCTE 146_ IFDYL 151_ SLSAI 156_ IDGKI 161_ FCVHG 166_ GLSPS 171_ IQTLD 176_ QIRTI 181_ DRKQE 186_ VPHDG 191_ PMCDL 196_ LWSDP 201_ EDTTG 206_ WGVSP 211_ RGAGY 216_ LFGSD 221_ VVAQF 226_ NAAND 231_ IDMIC 236_ RAHQL 241_ VMEGY 246_ KWHFN 251_ ETVLT 256_ VWSAP 261_ NYCYR 266_ CGNVA 271_ AILEL 276_ DEHLQ 281_ KDFII 286_ FEAAP 291_ QETRG 296_ IPSKK 301_PVADY
1: Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on Ser-140 (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin