Gamma-aminobutyric acid receptor-associated protein-like 2 (GABA(A) receptor-associated protein-like 2) (Ganglioside expression factor 2) (GEF-2) (General protein transport factor p16) (Golgi-associated ATPase enhancer of 16 kDa) (GATE-16) (MAP1 light chain 3-related protein)
1_MKWMF 6_ KEDHS 11_ LEHRC 16_ VESAK 21_ IRAKY 26_ PDRVP 31_ VIVEK 36_ VSGSQ 41_ IVDID 46_ KRKYL 51_ VPSDI 56_ TVAQF 61_ MWIIR 66_ KRIQL 71_ PSEKA 76_ IFLFV 81_ DKTVP 86_ QSSLT 91_ MGQLY 96_ EKEKD 101_ EDGFL 106_ YVAYS 111_GENTF
1: Ubiquitin-like modifier involved in intra-Golgi traffic (By similarity). Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation (By similarity). It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy (PubMed:20418806, PubMed:23209295). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (PubMed:20418806, PubMed:23209295). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20418806, PubMed:23209295)