Ubiquitin-conjugating enzyme E2 G2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme G2) (Ubiquitin carrier protein G2) (Ubiquitin-protein ligase G2)
1_MAGTA 6_ LKRLM 11_ AEYKQ 16_ LTLNP 21_ PEGIV 26_ AGPMN 31_ EENFF 36_ EWEAL 41_ IMGPE 46_ DTCFE 51_ FGVFP 56_ AILSF 61_ PLDYP 66_ LSPPK 71_ MRFTC 76_ EMFHP 81_ NIYPD 86_ GRVCI 91_ SILHA 96_ PGDDP 101_ MGYES 106_ SAERW 111_ SPVQS 116_ VEKIL 121_ LSVVS 126_ MLAEP 131_ NDESG 136_ ANVDA 141_ SKMWR 146_ DDREQ 151_ FYKIA 156_KQIVQ
1: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:20061386). In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:20061386). Involved in endoplasmic reticulum-associated degradation (ERAD) (PubMed:22607976). Required for sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its subsequent proteasomal degradation (PubMed:23223569)