Actin, cytoplasmic 1 (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
1_MDDDI 6_ AALVV 11_ DNGSG 16_ MCKAG 21_ FAGDD 26_ APRAV 31_ FPSIV 36_ GRPRH 41_ QGVMV 46_ GMGQK 51_ DSYVG 56_ DEAQS 61_ KRGIL 66_ TLKYP 71_ IEHGI 76_ VTNWD 81_ DMEKI 86_ WHHTF 91_ YNELR 96_ VAPEE 101_ HPVLL 106_ TEAPL 111_ NPKAN 116_ REKMT 121_ QIMFE 126_ TFNTP 131_ AMYVA 136_ IQAVL 141_ SLYAS 146_ GRTTG 151_ IVMDS 156_ GDGVT 161_ HTVPI 166_ YEGYA 171_ LPHAI 176_ LRLDL 181_ AGRDL 186_ TDYLM 191_ KILTE 196_ RGYSF 201_ TTTAE 206_ REIVR 211_ DIKEK 216_ LCYVA 221_ LDFEQ 226_ EMATA 231_ ASSSS 236_ LEKSY 241_ ELPDG 246_ QVITI 251_ GNERF 256_ RCPEA 261_ LFQPS 266_ FLGME 271_ SCGIH 276_ ETTFN 281_ SIMKC 286_ DVDIR 291_ KDLYA 296_ NTVLS 301_ GGTTM 306_ YPGIA 311_ DRMQK 316_ EITAL 321_ APSTM 326_ KIKII 331_ APPER 336_ KYSVW 341_ IGGSI 346_ LASLS 351_ TFQQM 356_ WISKQ 361_ EYDES 366_GPSIV
1: Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity)