Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3)
1_MQAIK 6_ CVVVG 11_ DGAVG 16_ KTCLL 21_ ISYTT 26_ NAFPG 31_ EYIPT 36_ VFDNY 41_ SANVM 46_ VDGKP 51_ VNLGL 56_ WDTAG 61_ QEDYD 66_ RLRPL 71_ SYPQT 76_ DVFLI 81_ CFSLV 86_ SPASF 91_ ENVRA 96_ KWYPE 101_ VRHHC 106_ PHTPI 111_ LLVGT 116_ KLDLR 121_ DDKDT 126_ IERLR 131_ DKKLA 136_ PITYP 141_ QGLAM 146_ AREIG 151_ SVKYL 156_ ECSAL 161_ TQRGL 166_ KTVFD 171_ EAIRA 176_ VLCPP 181_ PVKKP 186_GKKCT
1: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner