Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1)
1_MSASQ 6_ DSRSR 11_ DNGPD 16_ GMEPE 21_ GVIES 26_ NWNEI 31_ VDSFD 36_ DMNLS 41_ ESLLR 46_ GIYAY 51_ GFEKP 56_ SAIQQ 61_ RAILP 66_ CIKGY 71_ DVIAQ 76_ AQSGT 81_ GKTAT 86_ FAISI 91_ LQQIE 96_ LDLKA 101_ TQALV 106_ LAPTR 111_ ELAQQ 116_ IQKVV 121_ MALGD 126_ YMGAS 131_ CHACI 136_ GGTNV 141_ RAEVQ 146_ KLQME 151_ APHII 156_ VGTPG 161_ RVFDM 166_ LNRRY 171_ LSPKY 176_ IKMFV 181_ LDEAD 186_ EMLSR 191_ GFKDQ 196_ IYDIF 201_ QKLNS 206_ NTQVV 211_ LLSAT 216_ MPSDV 221_ LEVTK 226_ KFMRD 231_ PIRIL 236_ VKKEE 241_ LTLEG 246_ IRQFY 251_ INVER 256_ EEWKL 261_ DTLCD 266_ LYETL 271_ TITQA 276_ VIFIN 281_ TRRKV 286_ DWLTE 291_ KMHAR 296_ DFTVS 301_ AMHGD 306_ MDQKE 311_ RDVIM 316_ REFRS 321_ GSSRV 326_ LITTD 331_ LLARG 336_ IDVQQ 341_ VSLVI 346_ NYDLP 351_ TNREN 356_ YIHRI 361_ GRGGR 366_ FGRKG 371_ VAINM 376_ VTEED 381_ KRTLR 386_ DIETF 391_ YNTSI 396_ EEMPL 401_NVADL
1: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome (PubMed:20156963). In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. As a result, promotes cell proliferation and growth (PubMed:20156963)