Proteasome subunit alpha type-6 (27 kDa prosomal protein) (PROS-27) (p27K) (Macropain iota chain) (Multicatalytic endopeptidase complex iota chain) (Proteasome iota chain)
1_MSRGS 6_ SAGFD 11_ RHITI 16_ FSPEG 21_ RLYQV 26_ EYAFK 31_ AINQG 36_ GLTSV 41_ AVRGK 46_ DCAVI 51_ VTQKK 56_ VPDKL 61_ LDSST 66_ VTHLF 71_ KITEN 76_ IGCVM 81_ TGMTA 86_ DSRSQ 91_ VQRAR 96_ YEAAN 101_ WKYKY 106_ GYEIP 111_ VDMLC 116_ KRIAD 121_ ISQVY 126_ TQNAE 131_ MRPLG 136_ CCMIL 141_ IGIDE 146_ EQGPQ 151_ VYKCD 156_ PAGYY 161_ CGFKA 166_ TAAGV 171_ KQTES 176_ TSFLE 181_ KKVKK 186_ KFDWT 191_ FEQTV 196_ ETAIT 201_ CLSTV 206_ LSIDF 211_ KPSEI 216_ EVGVV 221_ TVENP 226_ KFRIL 231_ TEAEI 236_ DAHLV 241_ALAER
1: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)