Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
1_MQTIK 6_ CVVVG 11_ DGAVG 16_ KTCLL 21_ ISYTT 26_ NKFPS 31_ EYVPT 36_ VFDNY 41_ AVTVM 46_ IGGEP 51_ YTLGL 56_ FDTAG 61_ QEDYD 66_ RLRPL 71_ SYPQT 76_ DVFLV 81_ CFSVV 86_ SPSSF 91_ ENVKE 96_ KWVPE 101_ ITHHC 106_ PKTPF 111_ LLVGT 116_ QIDLR 121_ DDPST 126_ IEKLA 131_ KNKQK 136_ PITPE 141_ TAEKL 146_ ARDLK 151_ AVKYV 156_ ECSAL 161_ TQKGL 166_ KNVFD 171_ EAILA 176_ ALEPP 181_ EPKKS 186_RRCVL
1: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase (PubMed:15642749). Regulates cell migration (PubMed:17038317, PubMed:22843693). In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (PubMed:14978216). Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. In podocytes, facilitates filopodia and podosomes formation upon DOCK11-activation (PubMed:33523862). Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups (PubMed:26465210). Upon activation by PLEKHG4B, involved in actin cytoskeletal remodeling during epithelial cell-cell junction formation (PubMed:33310911)