Ras-related protein Rab-8A (EC 3.6.5.2) (Oncogene c-mel)
1_MAKTY 6_ DYLFK 11_ LLLIG 16_ DSGVG 21_ KTCVL 26_ FRFSE 31_ DAFNS 36_ TFIST 41_ IGIDF 46_ KIRTI 51_ ELDGK 56_ RIKLQ 61_ IWDTA 66_ GQERF 71_ RTITT 76_ AYYRG 81_ AMGIM 86_ LVYDI 91_ TNEKS 96_ FDNIR 101_ NWIRN 106_ IEEHA 111_ SADVE 116_ KMILG 121_ NKCDV 126_ NDKRQ 131_ VSKER 136_ GEKLA 141_ LDYGI 146_ KFMET 151_ SAKAN 156_ INVEN 161_ AFFTL 166_ ARDIK 171_ AKMDK 176_ KLEGN 181_ SPQGS 186_ NQGVK 191_ ITPDQ 196_ QKRSS 201_FFRCV
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB8A is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). Regulates the compacted morphology of the Golgi (PubMed:26209634). Together with MYO5B and RAB11A participates in epithelial cell polarization (PubMed:21282656). Also involved in membrane trafficking to the cilium and ciliogenesis (PubMed:21844891, PubMed:30398148, PubMed:20631154). Together with MICALL2, may also regulate adherens junction assembly (By similarity). May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis (By similarity). Involved in autophagy (PubMed:27103069). Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route (PubMed:32344433). Targeted to and stabilized on stressed lysosomes through LRRK2 phosphorylation (PubMed:30209220). Suppresses stress-induced lysosomal enlargement through EHBP1 and EHNP1L1 effector proteins (PubMed:30209220)