Signal peptidase complex subunit 3 (Microsomal signal peptidase 22/23 kDa subunit) (SPC22/23) (SPase 22/23 kDa subunit)
1_MNTVL 6_ SRANS 11_ LFAFS 16_ LSVMA 21_ ALTFG 26_ CFITT 31_ AFKDR 36_ SVPVR 41_ LHVSR 46_ IMLKN 51_ VEDFT 56_ GPRER 61_ SDLGF 66_ ITFDI 71_ TADLE 76_ NIFDW 81_ NVKQL 86_ FLYLS 91_ AEYST 96_ KNNAL 101_ NQVVL 106_ WDKIV 111_ LRGDN 116_ PKLLL 121_ KDMKT 126_ KYFFF 131_ DDGNG 136_ LKGNR 141_ NVTLT 146_ LSWNV 151_ VPNAG 156_ ILPLV 161_ TGSGH 166_ VSVPF 171_PDTYE
1: Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:27499293, PubMed:34388369). Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface (By similarity)
2: (Microbial infection) Plays an important role in virion production of flaviviruses such as West Nile virus, Japanese enchephalitis virus, Dengue virus type 2 and Yellow Fever virus