Signal recognition particle 54 kDa protein (SRP54) (EC 3.6.5.-)
1_MVLAD 6_ LGRKI 11_ TSALR 16_ SLSNA 21_ TIINE 26_ EVLNA 31_ MLKEV 36_ CTALL 41_ EADVN 46_ IKLVK 51_ QLREN 56_ VKSAI 61_ DLEEM 66_ ASGLN 71_ KRKMI 76_ QHAVF 81_ KELVK 86_ LVDPG 91_ VKAWT 96_ PTKGK 101_ QNVIM 106_ FVGLQ 111_ GSGKT 116_ TTCSK 121_ LAYYY 126_ QRKGW 131_ KTCLI 136_ CADTF 141_ RAGAF 146_ DQLKQ 151_ NATKA 156_ RIPFY 161_ GSYTE 166_ MDPVI 171_ IASEG 176_ VEKFK 181_ NENFE 186_ IIIVD 191_ TSGRH 196_ KQEDS 201_ LFEEM 206_ LQVAN 211_ AIQPD 216_ NIVYV 221_ MDASI 226_ GQACE 231_ AQAKA 236_ FKDKV 241_ DVASV 246_ IVTKL 251_ DGHAK 256_ GGGAL 261_ SAVAA 266_ TKSPI 271_ IFIGT 276_ GEHID 281_ DFEPF 286_ KTQPF 291_ ISKLL 296_ GMGDI 301_ EGLID 306_ KVNEL 311_ KLDDN 316_ EALIE 321_ KLKHG 326_ QFTLR 331_ DMYEQ 336_ FQNIM 341_ KMGPF 346_ SQILG 351_ MIPGF 356_ GTDFM 361_ SKGNE 366_ QESMA 371_ RLKKL 376_ MTIMD 381_ SMNDQ 386_ ELDST 391_ DGAKV 396_ FSKQP 401_ GRIQR 406_ VARGS 411_ GVSTR 416_ DVQEL 421_ LTQYT 426_ KFAQM 431_ VKKMG 436_ GIKGL 441_ FKGGD 446_ MSKNV 451_ SQSQM 456_ AKLNQ 461_ QMAKM 466_ MDPRV 471_ LHHMG 476_ GMAGL 481_ QSMMR 486_ QFQQG 491_ AAGNM 496_KGMMG
1: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane (PubMed:34020957). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes (PubMed:34020957). Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA (PubMed:28972538, PubMed:34020957). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA (PubMed:34020957). SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER (PubMed:34020957). Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA (By similarity). Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development (PubMed:28972538, PubMed:29914977)