Ras-related protein Rab-4B (EC 3.6.5.2)
1_MAETY 6_ DFLFK 11_ FLVIG 16_ SAGTG 21_ KSCLL 26_ HQFIE 31_ NKFKQ 36_ DSNHT 41_ IGVEF 46_ GSRVV 51_ NVGGK 56_ TVKLQ 61_ IWDTA 66_ GQERF 71_ RSVTR 76_ SYYRG 81_ AAGAL 86_ LVYDI 91_ TSRET 96_ YNSLA 101_ AWLTD 106_ ARTLA 111_ SPNIV 116_ VILCG 121_ NKKDL 126_ DPERE 131_ VTFLE 136_ ASRFA 141_ QENEL 146_ MFLET 151_ SALTG 156_ ENVEE 161_ AFLKC 166_ ARTIL 171_ NKIDS 176_ GELDP 181_ ERMGS 186_ GIQYG 191_ DASLR 196_ QLRQP 201_ RSAQA 206_VAPQP
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB4B mediates endosomal tethering and fusion through the interaction with RUFY1 and RAB14 (PubMed:20534812). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity)