Ras-related protein Rab-2A (EC 3.6.5.2)
1_MAYAY 6_ LFKYI 11_ IIGDT 16_ GVGKS 21_ CLLLQ 26_ FTDKR 31_ FQPVH 36_ DLTIG 41_ VEFGA 46_ RMITI 51_ DGKQI 56_ KLQIW 61_ DTAGQ 66_ ESFRS 71_ ITRSY 76_ YRGAA 81_ GALLV 86_ YDITR 91_ RDTFN 96_ HLTTW 101_ LEDAR 106_ QHSNS 111_ NMVIM 116_ LIGNK 121_ SDLES 126_ RREVK 131_ KEEGE 136_ AFARE 141_ HGLIF 146_ METSA 151_ KTASN 156_ VEEAF 161_ INTAK 166_ EIYEK 171_ IQEGV 176_ FDINN 181_ EANGI 186_ KIGPQ 191_ HAATN 196_ ATHAG 201_ NQGGQ 206_QAGGG
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (PubMed:37821429). RAB2A regulates autophagy by promoting autophagosome-lysosome fusion via recruitment of the HOPS endosomal tethering complex; this process involves autophagosomal RAB2A and lysosomal RAB39A recruitment of HOPS subcomplexes VPS39-VPS11 and VPS41-VPS16-VPS18-VPS33A, respectively, which assemble into a functional complex to mediate membrane tethering and SNAREs-driven membrane fusion (PubMed:37821429). Required for protein transport from the endoplasmic reticulum to the Golgi complex. Regulates the compacted morphology of the Golgi (PubMed:26209634). Together with RAB2B, redundantly required for efficient autophagic flux (PubMed:28483915)