Ras-related protein Rab-5B (EC 3.6.5.2)
1_MTSRS 6_ TARPN 11_ GQPQA 16_ SKICQ 21_ FKLVL 26_ LGESA 31_ VGKSS 36_ LVLRF 41_ VKGQF 46_ HEYQE 51_ STIGA 56_ AFLTQ 61_ SVCLD 66_ DTTVK 71_ FEIWD 76_ TAGQE 81_ RYHSL 86_ APMYY 91_ RGAQA 96_ AIVVY 101_ DITNQ 106_ ETFAR 111_ AKTWV 116_ KELQR 121_ QASPS 126_ IVIAL 131_ AGNKA 136_ DLANK 141_ RMVEY 146_ EEAQA 151_ YADDN 156_ SLLFM 161_ ETSAK 166_ TAMNV 171_ NDLFL 176_ AIAKK 181_ LPKSE 186_ PQNLG 191_ GAAGR 196_ SRGVD 201_ LHEQS 206_QQNKS
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion