C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (FB22) (Fusin) (HM89) (LCR1) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (Lipopolysaccharide-associated protein 3) (LAP-3) (LPS-associated protein 3) (NPYRL) (Stromal cell-derived factor 1 receptor) (SDF-1 receptor) (CD antigen CD184)
1_MEGIS 6_ IYTSD 11_ NYTEE 16_ MGSGD 21_ YDSMK 26_ EPCFR 31_ EENAN 36_ FNKIF 41_ LPTIY 46_ SIIFL 51_ TGIVG 56_ NGLVI 61_ LVMGY 66_ QKKLR 71_ SMTDK 76_ YRLHL 81_ SVADL 86_ LFVIT 91_ LPFWA 96_ VDAVA 101_ NWYFG 106_ NFLCK 111_ AVHVI 116_ YTVNL 121_ YSSVL 126_ ILAFI 131_ SLDRY 136_ LAIVH 141_ ATNSQ 146_ RPRKL 151_ LAEKV 156_ VYVGV 161_ WIPAL 166_ LLTIP 171_ DFIFA 176_ NVSEA 181_ DDRYI 186_ CDRFY 191_ PNDLW 196_ VVVFQ 201_ FQHIM 206_ VGLIL 211_ PGIVI 216_ LSCYC 221_ IIISK 226_ LSHSK 231_ GHQKR 236_ KALKT 241_ TVILI 246_ LAFFA 251_ CWLPY 256_ YIGIS 261_ IDSFI 266_ LLEII 271_ KQGCE 276_ FENTV 281_ HKWIS 286_ ITEAL 291_ AFFHC 296_ CLNPI 301_ LYAFL 306_ GAKFK 311_ TSAQH 316_ ALTSV 321_ SRGSS 326_ LKILS 331_ KGKRG 336_ GHSSV 341_ STESE 346_SSSFH
1: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:10452968, PubMed:18799424, PubMed:24912431, PubMed:28978524). Involved in the AKT signaling cascade (PubMed:24912431). Plays a role in regulation of cell migration, e.g. during wound healing (PubMed:28978524). Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels (PubMed:20228059). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity)
2: (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) for human immunodeficiency virus-1/HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus (PubMed:10074122, PubMed:10756055, PubMed:8849450, PubMed:8929542, PubMed:9427609)