Gene name: UBE2M

Uniprot entry:

P61081

Protein names:

NEDD8-conjugating enzyme Ubc12 (EC 2.3.2.34) (NEDD8 carrier protein) (Ubiquitin-conjugating enzyme E2 M)

Protein sequence:

1_MIKLF 6_ SLKQQ 11_ KKEEE 16_ SAGGT 21_ KGSSK 26_ KASAA 31_ QLRIQ 36_ KDINE 41_ LNLPK 46_ TCDIS 51_ FSDPD 56_ DLLNF 61_ KLVIC 66_ PDEGF 71_ YKSGK 76_ FVFSF 81_ KVGQG 86_ YPHDP 91_ PKVKC 96_ ETMVY 101_ HPNID 106_ LEGNV 111_ CLNIL 116_ REDWK 121_ PVLTI 126_ NSIIY 131_ GLQYL 136_ FLEPN 141_ PEDPL 146_ NKEAA 151_ EVLQN 156_ NRRLF 161_ EQNVQ 166_ RSMRG 171_ GYIGS 176_TYFER

Protein annotations

Protein functions:

1: Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation