Ras-related protein Rab-14
1_MATAP 6_ YNYSY 11_ IFKYI 16_ IIGDM 21_ GVGKS 26_ CLLHQ 31_ FTEKK 36_ FMADC 41_ PHTIG 46_ VEFGT 51_ RIIEV 56_ SGQKI 61_ KLQIW 66_ DTAGQ 71_ ERFRA 76_ VTRSY 81_ YRGAA 86_ GALMV 91_ YDITR 96_ RSTYN 101_ HLSSW 106_ LTDAR 111_ NLTNP 116_ NTVII 121_ LIGNK 126_ ADLEA 131_ QRDVT 136_ YEEAK 141_ QFAEE 146_ NGLLF 151_ LEASA 156_ KTGEN 161_ VEDAF 166_ LEAAK 171_ KIYQN 176_ IQDGS 181_ LDLNA 186_ AESGV 191_ QHKPS 196_ APQGG 201_ RLTSE 206_PQPQR
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:22595670). Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development (By similarity). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion (PubMed:22595670). Mediates endosomal tethering and fusion through the interaction with RUFY1 and RAB4B (PubMed:20534812). Interaction with RAB11FIP1 may function in the process of neurite formation (PubMed:26032412)