Actin-related protein 3 (Actin-like protein 3)
1_MAGRL 6_ PACVV 11_ DCGTG 16_ YTKLG 21_ YAGNT 26_ EPQFI 31_ IPSCI 36_ AIKES 41_ AKVGD 46_ QAQRR 51_ VMKGV 56_ DDLDF 61_ FIGDE 66_ AIEKP 71_ TYATK 76_ WPIRH 81_ GIVED 86_ WDLME 91_ RFMEQ 96_ VIFKY 101_ LRAEP 106_ EDHYF 111_ LLTEP 116_ PLNTP 121_ ENREY 126_ TAEIM 131_ FESFN 136_ VPGLY 141_ IAVQA 146_ VLALA 151_ ASWTS 156_ RQVGE 161_ RTLTG 166_ TVIDS 171_ GDGVT 176_ HVIPV 181_ AEGYV 186_ IGSCI 191_ KHIPI 196_ AGRDI 201_ TYFIQ 206_ QLLRD 211_ REVGI 216_ PPEQS 221_ LETAK 226_ AVKER 231_ YSYVC 236_ PDLVK 241_ EFNKY 246_ DTDGS 251_ KWIKQ 256_ YTGIN 261_ AISKK 266_ EFSID 271_ VGYER 276_ FLGPE 281_ IFFHP 286_ EFANP 291_ DFTQP 296_ ISEVV 301_ DEVIQ 306_ NCPID 311_ VRRPL 316_ YKNIV 321_ LSGGS 326_ TMFRD 331_ FGRRL 336_ QRDLK 341_ RTVDA 346_ RLKLS 351_ EELSG 356_ GRLKP 361_ KPIDV 366_ QVITH 371_ HMQRY 376_ AVWFG 381_ GSMLA 386_ STPEF 391_ YQVCH 396_ TKKDY 401_ EEIGP 406_ SICRH 411_NPVFG
1: ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation (PubMed:29058690). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Plays a role in ciliogenesis (PubMed:20393563)