Actin-related protein 2 (Actin-like protein 2)
1_MDSQG 6_ RKVVV 11_ CDNGT 16_ GFVKC 21_ GYAGS 26_ NFPEH 31_ IFPAL 36_ VGRPI 41_ IRSTT 46_ KVGNI 51_ EIKDL 56_ MVGDE 61_ ASELR 66_ SMLEV 71_ NYPME 76_ NGIVR 81_ NWDDM 86_ KHLWD 91_ YTFGP 96_ EKLNI 101_ DTRNC 106_ KILLT 111_ EPPMN 116_ PTKNR 121_ EKIVE 126_ VMFET 131_ YQFSG 136_ VYVAI 141_ QAVLT 146_ LYAQG 151_ LLTGV 156_ VVDSG 161_ DGVTH 166_ ICPVY 171_ EGFSL 176_ PHLTR 181_ RLDIA 186_ GRDIT 191_ RYLIK 196_ LLLLR 201_ GYAFN 206_ HSADF 211_ ETVRM 216_ IKEKL 221_ CYVGY 226_ NIEQE 231_ QKLAL 236_ ETTVL 241_ VESYT 246_ LPDGR 251_ IIKVG 256_ GERFE 261_ APEAL 266_ FQPHL 271_ INVEG 276_ VGVAE 281_ LLFNT 286_ IQAAD 291_ IDTRS 296_ EFYKH 301_ IVLSG 306_ GSTMY 311_ PGLPS 316_ RLERE 321_ LKQLY 326_ LERVL 331_ KGDVE 336_ KLSKF 341_ KIRIE 346_ DPPRR 351_ KHMVF 356_ LGGAV 361_ LADIM 366_ KDKDN 371_ FWMTR 376_ QEYQE 381_ KGVRV 386_LEKLG
1: ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation (PubMed:29058690). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947)