COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15)
1_MSDME 6_ DDFMC 11_ DDEED 16_ YDLEY 21_ SEDSN 26_ SEPNV 31_ DLENQ 36_ YYNSK 41_ ALKED 46_ DPKAA 51_ LSSFQ 56_ KVLEL 61_ EGEKG 66_ EWGFK 71_ ALKQM 76_ IKINF 81_ KLTNF 86_ PEMMN 91_ RYKQL 96_ LTYIR 101_ SAVTR 106_ NYSEK 111_ SINSI 116_ LDYIS 121_ TSKQM 126_ DLLQE 131_ FYETT 136_ LEALK 141_ DAKND 146_ RLWFK 151_ TNTKL 156_ GKLYL 161_ EREEY 166_ GKLQK 171_ ILRQL 176_ HQSCQ 181_ TDDGE 186_ DDLKK 191_ GTQLL 196_ EIYAL 201_ EIQMY 206_ TAQKN 211_ NKKLK 216_ ALYEQ 221_ SLHIK 226_ SAIPH 231_ PLIMG 236_ VIREC 241_ GGKMH 246_ LREGE 251_ FEKAH 256_ TDFFE 261_ AFKNY 266_ DESGS 271_ PRRTT 276_ CLKYL 281_ VLANM 286_ LMKSG 291_ INPFD 296_ SQEAK 301_ PYKND 306_ PEILA 311_ MTNLV 316_ SAYQN 321_ NDITE 326_ FEKIL 331_ KTNHS 336_ NIMDD 341_ PFIRE 346_ HIEEL 351_ LRNIR 356_ TQVLI 361_ KLIKP 366_ YTRIH 371_ IPFIS 376_ KELNI 381_ DVADV 386_ ESLLV 391_ QCILD 396_ NTIHG 401_ RIDQV 406_ NQLLE 411_ LDHQK 416_ RGGAR 421_ YTALD 426_ KWTNQ 431_ LNSLN 436_QAVVS
1: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1