ATP-binding cassette sub-family E member 1 (2'-5'-oligoadenylate-binding protein) (HuHP68) (RNase L inhibitor) (Ribonuclease 4 inhibitor) (RNS4I)
1_MADKL 6_ TRIAI 11_ VNHDK 16_ CKPKK 21_ CRQEC 26_ KKSCP 31_ VVRMG 36_ KLCIE 41_ VTPQS 46_ KIAWI 51_ SETLC 56_ IGCGI 61_ CIKKC 66_ PFGAL 71_ SIVNL 76_ PSNLE 81_ KETTH 86_ RYCAN 91_ AFKLH 96_ RLPIP 101_ RPGEV 106_ LGLVG 111_ TNGIG 116_ KSTAL 121_ KILAG 126_ KQKPN 131_ LGKYD 136_ DPPDW 141_ QEILT 146_ YFRGS 151_ ELQNY 156_ FTKIL 161_ EDDLK 166_ AIIKP 171_ QYVDQ 176_ IPKAA 181_ KGTVG 186_ SILDR 191_ KDETK 196_ TQAIV 201_ CQQLD 206_ LTHLK 211_ ERNVE 216_ DLSGG 221_ ELQRF 226_ ACAVV 231_ CIQKA 236_ DIFMF 241_ DEPSS 246_ YLDVK 251_ QRLKA 256_ AITIR 261_ SLINP 266_ DRYII 271_ VVEHD 276_ LSVLD 281_ YLSDF 286_ ICCLY 291_ GVPSA 296_ YGVVT 301_ MPFSV 306_ REGIN 311_ IFLDG 316_ YVPTE 321_ NLRFR 326_ DASLV 331_ FKVAE 336_ TANEE 341_ EVKKM 346_ CMYKY 351_ PGMKK 356_ KMGEF 361_ ELAIV 366_ AGEFT 371_ DSEIM 376_ VMLGE 381_ NGTGK 386_ TTFIR 391_ MLAGR 396_ LKPDE 401_ GGEVP 406_ VLNVS 411_ YKPQK 416_ ISPKS 421_ TGSVR 426_ QLLHE 431_ KIRDA 436_ YTHPQ 441_ FVTDV 446_ MKPLQ 451_ IENII 456_ DQEVQ 461_ TLSGG 466_ ELQRV 471_ ALALC 476_ LGKPA 481_ DVYLI 486_ DEPSA 491_ YLDSE 496_ QRLMA 501_ ARVVK 506_ RFILH 511_ AKKTA 516_ FVVEH 521_ DFIMA 526_ TYLAD 531_ RVIVF 536_ DGVPS 541_ KNTVA 546_ NSPQT 551_ LLAGM 556_ NKFLS 561_ QLEIT 566_ FRRDP 571_ NNYRP 576_ RINKL 581_ NSIKD 586_ VEQKK 591_SGNYF
1: Nucleoside-triphosphatase (NTPase) involved in ribosome recycling by mediating ribosome disassembly (PubMed:20122402, PubMed:21448132). Able to hydrolyze ATP, GTP, UTP and CTP (PubMed:20122402). Splits ribosomes into free 60S subunits and tRNA- and mRNA-bound 40S subunits (PubMed:20122402, PubMed:21448132). Acts either after canonical termination facilitated by release factors (ETF1/eRF1) or after recognition of stalled and vacant ribosomes by mRNA surveillance factors (PELO/Pelota) (PubMed:20122402, PubMed:21448132). Involved in the No-Go Decay (NGD) pathway: recruited to stalled ribosomes by the Pelota-HBS1L complex, and drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132). Also plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed:29861391). As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage; this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy (PubMed:29861391). RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL (PubMed:9660177). Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway (PubMed:11585831, PubMed:9660177, PubMed:9847332)
2: (Microbial infection) May act as a chaperone for post-translational events during HIV-1 capsid assembly
3: (Microbial infection) Plays a role in the down-regulation of the 2-5A/RNASEL pathway during encephalomyocarditis virus (EMCV) and HIV-1 infections