Ras-related protein Rap-1b (EC 3.6.5.2) (GTP-binding protein smg p21B)
1_MREYK 6_ LVVLG 11_ SGGVG 16_ KSALT 21_ VQFVQ 26_ GIFVE 31_ KYDPT 36_ IEDSY 41_ RKQVE 46_ VDAQQ 51_ CMLEI 56_ LDTAG 61_ TEQFT 66_ AMRDL 71_ YMKNG 76_ QGFAL 81_ VYSIT 86_ AQSTF 91_ NDLQD 96_ LREQI 101_ LRVKD 106_ TDDVP 111_ MILVG 116_ NKCDL 121_ EDERV 126_ VGKEQ 131_ GQNLA 136_ RQWNN 141_ CAFLE 146_ SSAKS 151_ KINVN 156_ EIFYD 161_ LVRQI 166_ NRKTP 171_ VPGKA 176_RKKSS
1: GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function