Ras-related protein Rap-2b (EC 3.6.5.2)
1_MREYK 6_ VVVLG 11_ SGGVG 16_ KSALT 21_ VQFVT 26_ GSFIE 31_ KYDPT 36_ IEDFY 41_ RKEIE 46_ VDSSP 51_ SVLEI 56_ LDTAG 61_ TEQFA 66_ SMRDL 71_ YIKNG 76_ QGFIL 81_ VYSLV 86_ NQQSF 91_ QDIKP 96_ MRDQI 101_ IRVKR 106_ YERVP 111_ MILVG 116_ NKVDL 121_ EGERE 126_ VSYGE 131_ GKALA 136_ EEWSC 141_ PFMET 146_ SAKNK 151_ ASVDE 156_ LFAEI 161_ VRQMN 166_ YAAQP 171_ NGDEG 176_CCSAC
1: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells