Protein max (Class D basic helix-loop-helix protein 4) (bHLHd4) (Myc-associated factor X)
1_MSDND 6_ DIEVE 11_ SDEEQ 16_ PRFQS 21_ AADKR 26_ AHHNA 31_ LERKR 36_ RDHIK 41_ DSFHS 46_ LRDSV 51_ PSLQG 56_ EKASR 61_ AQILD 66_ KATEY 71_ IQYMR 76_ RKNHT 81_ HQQDI 86_ DDLKR 91_ QNALL 96_ EQQVR 101_ ALEKA 106_ RSSAQ 111_ LQTNY 116_ PSSDN 121_ SLYTN 126_ AKGST 131_ ISAFD 136_ GGSDS 141_ SSESE 146_ PEEPQ 151_SRKKL
1: Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements