Proteasome activator complex subunit 3 (11S regulator complex subunit gamma) (REG-gamma) (Activator of multicatalytic protease subunit 3) (Ki nuclear autoantigen) (Proteasome activator 28 subunit gamma) (PA28g) (PA28gamma)
1_MASLL 6_ KVDQE 11_ VKLKV 16_ DSFRE 21_ RITSE 26_ AEDLV 31_ ANFFP 36_ KKLLE 41_ LDSFL 46_ KEPIL 51_ NIHDL 56_ TQIHS 61_ DMNLP 66_ VPDPI 71_ LLTNS 76_ HDGLD 81_ GPTYK 86_ KRRLD 91_ ECEEA 96_ FQGTK 101_ VFVMP 106_ NGMLK 111_ SNQQL 116_ VDIIE 121_ KVKPE 126_ IRLLI 131_ EKCNT 136_ VKMWV 141_ QLLIP 146_ RIEDG 151_ NNFGV 156_ SIQEE 161_ TVAEL 166_ RTVES 171_ EAASY 176_ LDQIS 181_ RYYIT 186_ RAKLV 191_ SKIAK 196_ YPHVE 201_ DYRRT 206_ VTEID 211_ EKEYI 216_ SLRLI 221_ ISELR 226_ NQYVT 231_ LHDMI 236_ LKNIE 241_ KIKRP 246_RSSNA
1: Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978)