Heart- and neural crest derivatives-expressed protein 2 (Class A basic helix-loop-helix protein 26) (bHLHa26) (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND)
1_MSLVG 6_ GFPHH 11_ PVVHH 16_ EGYPF 21_ AAAAA 26_ AAAAA 31_ AASRC 36_ SHEEN 41_ PYFHG 46_ WLIGH 51_ PEMSP 56_ PDYSM 61_ ALSYS 66_ PEYAS 71_ GAAGL 76_ DHSHY 81_ GGVPP 86_ GAGPP 91_ GLGGP 96_ RPVKR 101_ RGTAN 106_ RKERR 111_ RTQSI 116_ NSAFA 121_ ELREC 126_ IPNVP 131_ ADTKL 136_ SKIKT 141_ LRLAT 146_ SYIAY 151_ LMDLL 156_ AKDDQ 161_ NGEAE 166_ AFKAE 171_ IKKTD 176_ VKEEK 181_ RKKEL 186_ NEILK 191_ STVSS 196_ NDKKT 201_ KGRTG 206_ WPQHV 211_WALEL
1: Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Also plays an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity)