Protein mago nashi homolog
1_MESDF 6_ YLRYY 11_ VGHKG 16_ KFGHE 21_ FLEFE 26_ FRPDG 31_ KLRYA 36_ NNSNY 41_ KNDVM 46_ IRKEA 51_ YVHKS 56_ VMEEL 61_ KRIID 66_ DSEIT 71_ KEDDA 76_ LWPPP 81_ DRVGR 86_ QELEI 91_ VIGDE 96_ HISFT 101_ TSKIG 106_ SLIDV 111_ NQSKD 116_ PEGLR 121_ VFYYL 126_ VQDLK 131_ CLVFS 136_ LIGLH 141_FKIKP
1: Required for pre-mRNA splicing as component of the spliceosome (PubMed:11991638). Plays a redundant role with MAGOHB as core component of the exon junction complex (EJC) and in the nonsense-mediated decay (NMD) pathway (PubMed:23917022). The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S pre-initiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly