Insulin gene enhancer protein ISL-1 (Islet-1)
1_MGDMG 6_ DPPKK 11_ KRLIS 16_ LCVGC 21_ GNQIH 26_ DQYIL 31_ RVSPD 36_ LEWHA 41_ ACLKC 46_ AECNQ 51_ YLDES 56_ CTCFV 61_ RDGKT 66_ YCKRD 71_ YIRLY 76_ GIKCA 81_ KCSIG 86_ FSKND 91_ FVMRA 96_ RSKVY 101_ HIECF 106_ RCVAC 111_ SRQLI 116_ PGDEF 121_ ALRED 126_ GLFCR 131_ ADHDV 136_ VERAS 141_ LGAGD 146_ PLSPL 151_ HPARP 156_ LQMAA 161_ EPISA 166_ RQPAL 171_ RPHVH 176_ KQPEK 181_ TTRVR 186_ TVLNE 191_ KQLHT 196_ LRTCY 201_ AANPR 206_ PDALM 211_ KEQLV 216_ EMTGL 221_ SPRVI 226_ RVWFQ 231_ NKRCK 236_ DKKRS 241_ IMMKQ 246_ LQQQQ 251_ PNDKT 256_ NIQGM 261_ TGTPM 266_ VAASP 271_ ERHDG 276_ GLQAN 281_ PVEVQ 286_ SYQPP 291_ WKVLS 296_ DFALQ 301_ SDIDQ 306_ PAFQQ 311_ LVNFS 316_ EGGPG 321_ SNSTG 326_ SEVAS 331_ MSSQL 336_ PDTPN 341_SMVAS
1: DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1 (By similarity). Binds to insulin gene enhancer sequences (By similarity). Essential for heart development. Marker of one progenitor cell population that give rise to the outflow tract, right ventricle, a subset of left ventricular cells, and a large number of atrial cells as well, its function is required for these progenitors to contribute to the heart. Controls the expression of FGF and BMP growth factors in this cell population and is required for proliferation and survival of cells within pharyngeal foregut endoderm and adjacent splanchnic mesoderm as well as for migration of cardiac progenitors into the heart (By similarity)