V-type proton ATPase subunit d 1 (V-ATPase subunit d 1) (32 kDa accessory protein) (V-ATPase 40 kDa accessory protein) (V-ATPase AC39 subunit) (p39) (Vacuolar proton pump subunit d 1)
1_MSFFP 6_ ELYFN 11_ VDNGY 16_ LEGLV 21_ RGLKA 26_ GVLSQ 31_ ADYLN 36_ LVQCE 41_ TLEDL 46_ KLHLQ 51_ STDYG 56_ NFLAN 61_ EASPL 66_ TVSVI 71_ DDRLK 76_ EKMVV 81_ EFRHM 86_ RNHAY 91_ EPLAS 96_ FLDFI 101_ TYSYM 106_ IDNVI 111_ LLITG 116_ TLHQR 121_ SIAEL 126_ VPKCH 131_ PLGSF 136_ EQMEA 141_ VNIAQ 146_ TPAEL 151_ YNAIL 156_ VDTPL 161_ AAFFQ 166_ DCISE 171_ QDLDE 176_ MNIEI 181_ IRNTL 186_ YKAYL 191_ ESFYK 196_ FCTLL 201_ GGTTA 206_ DAMCP 211_ ILEFE 216_ ADRRA 221_ FIITI 226_ NSFGT 231_ ELSKE 236_ DRAKL 241_ FPHCG 246_ RLYPE 251_ GLAQL 256_ ARADD 261_ YEQVK 266_ NVADY 271_ YPEYK 276_ LLFEG 281_ AGSNP 286_ GDKTL 291_ EDRFF 296_ EHEVK 301_ LNKLA 306_ FLNQF 311_ HFGVF 316_ YAFVK 321_ LKEQE 326_ CRNIV 331_ WIAEC 336_ IAQRH 341_ RAKID 346_NYIPI
1: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:28296633, PubMed:30374053, PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:30374053). May play a role in coupling of proton transport and ATP hydrolysis (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity)