Endogenous retrovirus group K member 25 Env polyprotein (Envelope polyprotein) (HERV-K_11q22.1 provirus ancestral Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]
1_MNPSE 6_ MQRKA 11_ PPRRR 16_ RHRNR 21_ APLTH 26_ KMNKM 31_ VTSEE 36_ QMKLP 41_ STKKA 46_ EPPTW 51_ AQLKK 56_ LTQLA 61_ TKYLE 66_ NTKVT 71_ QTPES 76_ MLLAA 81_ LMIVS 86_ MVVSL 91_ PMPAG 96_ AAAAN 101_ YTYWA 106_ YVPFP 111_ PLIRA 116_ VTWMD 121_ NPIEV 126_ YVNDS 131_ VWVPG 136_ PIDDR 141_ CPAKP 146_ EEEGM 151_ MINIS 156_ IGYRY 161_ PPICL 166_ GTAPG 171_ CLMPA 176_ VQNWL 181_ VEVPI 186_ VSPIS 191_ RFTYH 196_ MVSGM 201_ SLRPR 206_ VNYLQ 211_ DFSYQ 216_ RSLKF 221_ RPKGK 226_ PCPKE 231_ IPKES 236_ KNTEV 241_ LVWEE 246_ CVANS 251_ AVILQ 256_ NNEFG 261_ TIIDW 266_ APRGQ 271_ FYHNC 276_ SGQTQ 281_ SCPSA 286_ QVSPA 291_ VDSDL 296_ TESLD 301_ KHKHK 306_ KLQSF 311_ YPWEW 316_ GEKGI 321_ STPRP 326_ KIVSP 331_ VSGPE 336_ HPELW 341_ RLTVA 346_ SHHIR 351_ IWSGN 356_ QTLET 361_ RDRKP 366_ FYTVD 371_ LNSSL 376_ TVPLQ 381_ SCVKP 386_ PYMLV 391_ VGNIV 396_ IKPDS 401_ QTITC 406_ ENCRL 411_ LTCID 416_ STFNW 421_ QHRIL 426_ LVRAR 431_ EGVWI 436_ PVSMD 441_ RPWEA 446_ SPSIH 451_ ILTEV 456_ LKGVL 461_ NRSKR 466_ FIFTL 471_ IAVIM 476_ GLIAV 481_ TATGA 486_ VAGVA 491_ LHSSV 496_ QSVNF 501_ VNDWQ 506_ KNSTR 511_ LWNSQ 516_ SSIDQ 521_ KLANQ 526_ INDLR 531_ QTVIW 536_ MGDRL 541_ MSLEH 546_ RFQLQ 551_ CDWNT 556_ SDFCI 561_ TPQIY 566_ NESEH 571_ HWDMV 576_ RRHLQ 581_ GREDN 586_ LTLDI 591_ SKLKE 596_ QIFKA 601_ SKAHL 606_ NLVPG 611_ TEAIA 616_ GVADG 621_ LANLN 626_ PVTWV 631_ KTIGS 636_ TTIIN 641_ LILIL 646_ VCLFC 651_ LLLVC 656_RCTQQ
1: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution (By similarity)
2: SU mediates receptor recognition
3: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity)