Endogenous retrovirus group K member 21 Rec protein (HERV-K_12q14.1 provirus Rec protein)
1_MHPSE 6_ MQRKA 11_ PPRRR 16_ RHRNR 21_ APLTH 26_ KMNKM 31_ VTSEQ 36_ MKLPS 41_ TKKAE 46_ PPTWA 51_ QLKKL 56_ TQLAT 61_ KYLEN 66_ TKVTQ 71_ TPESM 76_ LLAAL 81_ MIVSM 86_ VSAGV 91_ PNSSE 96_ETATI
1: Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts (By similarity)